Likely a connection issue. If you're under warranty still have your dealer look at it.
If not under warranty then first thing to try would be to disconnect the battery and give it a few minutes for the computers to fully reset. If that doesn't help then take apart the dash to get to the connector for those buttons - disconnect, inspect connection, and if all seems good then reconnect and see if that helped. (Make sure to disconnect the battery when working on the dash in case you short something by accident)
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